Q: Which ONE of the following statements concerning single-pan electronic balances as replacements for the Class III balance is true?
Explanation: While free-swinging pan balances based upon the torsion principle are traditional in pharmacy, the more sophisticated electronic balances are suitable provided that they meet USP/NF standards of a sensitivity requirement of 6 mg or less (better). While the usual largest quantity to be weighed on the torsion balance without causing damage was 120 g,this is not an absolute quantity. The most important value for compounding is the allowable error, which should be not more than ± 5%.
Q: Which of the types of topical bases should be formulated to include an antimicrobial preservative? I. aqueous gels II. water in oil (W/ 0) emulsion III. oil in water (O/W) emulsion
Q: Which of the following are liposomal formulations of amphotericin? I. Abelcet injection II. Amphocil injection III. Docil injection
Explanation: Abelcet is a sterile suspension and Amphotec is a sterile lyophilized powder for reconstitution, both intended for intravenous administration. While both are liposome for- mulas, the particle size of each differ; thus, they are used or are targeted for different organs and are not interchangeable. Doxil is a liposome form of doxorubicin HCl and ap- pears to have less toxicity than the parent compound.
Q: Which of the following cautions must be considered when dispensing most parenteralli posomal products? I. Do not reconstitute with sodium chloride injection. II. Dosing may differ from that of the conventional drug solutions. III. Infuse only through administration sets that have an in-line filter.
Explanation: Liposomal powders are usually reconstituted using sterile water for injection. Other diluents such as sodium chloride injection may cause breakage of the liposomal system. Since many of the liposomal products are formulated as "targeted drug delivery systems," the drug present will concentrate in areas of the body in which they are most active. Thus,the drug dose required is often less. Consequently, if the larger conventional dose is given, toxic levels of the drug may occur. Conversely, if the