Pharmaceutical Care

Q: Asthmatic patients with a documented allergy to aspirin should NOT receive

(a) :  ibuprofen (Motrin)
(b) :  acetaminophen (Tylenol)
(c) :  salmeterol (Serevent)
(d) :  pentazocine (Talwin)
(e) :  albuterol (Proventil)
Answer:  ibuprofen (Motrin)
Explanation:   Aspirin allergy in association with asthma is cause for serious concern. Asthma, rhinorrhea, and nasal polyps usually accompany this type of aspirin intolerance, which occurs in about 4 to 20% of asthmatic patients. These patients appear to exhibit a high degree of cross-reactivity to other NSAIDs, such as ibuprofen.

Q: Lansoprazole (Prevacid) inhibits gastric acid secretion as a result of

(a) :  H2-receptor antagonism
(b) :  proton pump inhibition
(c) :  anticholinergic action
(d) :  buffer generation
(e) :  Helicobacter pylori inhibition
Answer:  proton pump inhibition
Explanation:   Lansoprazole (Prevacid) and omeprazole (Prilosec) reduce gastric acidity by inhibiting the "proton pump" within the gastric mucosa. They are commonly used in the treatment of peptic ulcer disease, gastroesophageal reflux disease (GERD) or pathological hypersecretory conditions.

Q: The primary advantage of oxaprozin over lost other nonsteroidal anti-inflammatory drugs (NSAIDs) is that it

(a) :  does not interact with warfarin
(b) :  may be used concomitantly with aspirin
(c) :  may be given on a once-a-day schedule
(d) :  has a cytoprotective effect
(e) :  has essentially no adverse GI effects
Answer:  has a cytoprotective effect
Explanation:  Although the NSAIDs are structurally different, they all possess similar pharmacological properties and all inhibit prostaglandin synthesis. Furthermore, these drugs produce similar adverse effects, including gastrointestinal (GI) intolerance. Oxaprozin (Daypro) has the longest half-life of the group (approximately 42 to 50 hours) and is recommended to be given on a once-a-day basis.

Q: A blood sugar concentration within normal limits for a fasting adult is

(a) :  100 mg/dL
(b) :  200 mg/dL
(c) :  300 mg/dL
(d) :  400 mg/dL
(e) :  500 mg/dL
Answer:  100 mg/dL
Explanation:   Normal fasting blood sugar values for adults range from 80 to 120 mg/dL (or 80 to 120 mg%). When the fasting blood sugar levels exceed 120 mg/dL, diabetes mellitus should be suspected. Levels below 60 mg/dL may suggest insulin overdosage, glucagon deficiencies, and/or hypoactivity of various endocrine glands.

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