Pharmacy mcqs

Q: Ramipril HCl (Altace) can best be classified as a (an)

(a) :  beta-adrenergic blocking agent
(b) :  vasodilator
(c) :  calcium channel blocker
(d) :  angiotensin-converting enzyme inhibitor
(e) :  alpha-adrenergic blocking agent
Answer:  angiotensin-converting enzyme inhibitor
Explanation:   Ramipril (Altace) is an angiotensin-con verting enzyme (ACE) inhibitor indicated for the treatment of hypertension. When admin istered orally, antihypertensive action gener ally occurs within 1 to 2 hours. The drug's action persists for 24 hours. This permits single daily dosing.

Q: A patient complains about a headache that is localized in the periorbitalarea and seems to be worse in the morning than in the after-noon. Which of the following would be the best way to characterize the headache?

(a) :  tumorigenic
(b) :  vascular-migraine
(c) :  muscle contraction
(d) :  eye strain
(e) :  sinus
Answer:  sinus
Explanation:   Patients with sinus headaches generally experience pain in the periorbital area. Pain is usually greatest on awakening because of the accumulation of fluid in the sinus cavities.

Q: Which of the following agents is (are) classi-fied as a leukotriene receptor antagonist? I. ipratropium bromide II. zileuton III. montelukast sodium

(a) :  I only
(b) :  III only
(c) :  I and II only
(d) :  II and III only
(e) :  I, II, and III only
Answer:  II and III only
Explanation:   Zileuton (Zyflo) and montelukast sodium (Singulair) are leukotriene receptor antagonists. Since leukotrienes are associated with causing asthmatic symptoms, the use of these drugs reduces the likelihood of asthma attacks.

Q: A common building block for liposomes are the

(a) :  anionic surfactants plus mineral oil
(b) :  nonionic surfactants plus mineral oil
(c) :  phospholipids
(d) :  polyethylene glycols
(e) :  straight-chain hydrocarbons combined with phosphoric acid
Answer:  phospholipids
Explanation:  Liposomes are small vesicles of a bilaye of phospholipid encapsulating an aqueou compartment. Since phospholipids have both hydrophilic and hydrophobic portions, eithe lipophilic or hydrophilic drugs may be incorporated into the structure. Liposomes may vary in shape, usually with sizes between 0.5 and 100 microns.

Q: An adult patient who ingested 30 acetaminophen tablets (325 mg/tab) 6 hours ago should be treated with/by

(a) :  EDTA infusion
(b) :  ipecac syrup
(c) :  activated charcoal
(d) :  N-acetylcysteine
(e) :  probenecid
Answer:  N-acetylcysteine
Explanation:   Because the drug was ingested 6 hours ago, the likelihood of removing a large amount of drug from this patient's stomach with ipecac syrup is small. Activated char- coal effectively binds acetaminophen if given soon after ingestion, but its use here is also unlikely to be of value because of the elapsed time. N-acetylcysteine serves as a glutathione substitute that effectively binds the toxin and permits it to be excreted in the urine. N-acetylcysteine is given orally or by lavage tube.

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